The mixture of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric clients lower than 6 decades of age, mainly because The mix could lead to lethal respiratory depression in this age populace.
Nursing mothers taking codeine can even have bigger morphine degrees inside their breast milk When they are extremely-immediate metabolizers. These better levels of morphine in breast milk may lead to existence-threatening or deadly Uncomfortable side effects in nursing toddlers. Instruct nursing mothers to Look ahead to signs of morphine toxicity within their infants together with enhanced sleepiness (much more than common), trouble breastfeeding, breathing challenges, or limpness.
It can be difficult to figure out what constitutes a regular toxic or lethal dose. On the other hand, the lethal oral dose of codeine in an Grownup is described to become during the choice of 0.
Narcotic analgesics may well lead to nausea and vomiting by stimulating the chemoreceptor trigger zone (CTZ); on the other hand, Additionally they depress the vomiting Heart, in order that subsequent doses are unlikely to supply vomiting. Nausea is small after regular oral doses of codeine.
The mixture of promethazine hydrochloride and codeine phosphate need to be used with caution in pediatric individual six many years and more mature (see WARNINGS – Use in Pediatric People).
This is not an entire list of attainable Unintended effects. In the event you detect other Unintended effects not outlined above, contact your health practitioner or pharmacist.
This medication may possibly consist of sugar and/or Alcoholic beverages. Warning is recommended When you've got diabetic issues, Liquor dependence, or liver disease. Question your health practitioner or pharmacist about working with this merchandise safely and securely.
Nursing moms taking codeine can also have increased morphine ranges in their breast milk If they're ultra-rapid metabolizers. These larger amounts of morphine in breast milk may well result in daily life-threatening or deadly Unintended effects in nursing infants. Instruct nursing mothers to Look ahead to indications of morphine toxicity within their infants including enhanced sleepiness (in excess of standard), issues breastfeeding, respiration troubles, or limpness.
We anticipate reposting the photographs once we have been equipped detect and filter out visuals that do not match the knowledge supplied within the drug labels. NDC Codes
Narcotic analgesics cross the placental barrier. The nearer to supply along with the much larger the dose made use of, the greater the potential for respiratory despair while in the newborn. Narcotic analgesics really should be averted all through labor if delivery of a premature infant is anticipated. In case the mother has been given narcotic analgesics in the course of labor, new child infants must be noticed closely for indications of respiratory despair.
Anticholinergics – Concomitant utilization of other agents with anticholinergic Houses need to be carried out with warning.
If you are pretty Promethazine codeine syrup sleepy or have issue waking up just after using this medication, prevent getting this medication and talk with your physician or pharmacist immediately. Your dosage might should be decreased.
Codeine and its salts are very well absorbed following equally oral and parenteral administration. Codeine is about two/3 as efficient orally as parenterally. Codeine is metabolized principally while in the liver by enzymes from the endoplasmic reticulum, the place it undergoes O-demethylation, N-demethylation, and partial conjugation with glucuronic acid.
Narcotic analgesics may well cause nausea and vomiting by stimulating the chemoreceptor cause zone (CTZ); nonetheless, Additionally they depress the vomiting Middle, in order that subsequent doses are unlikely to supply vomiting. Nausea is minimum immediately after typical oral doses of codeine.